, Baicalin is known to inhibit HIV replication with a potency in the range of 43.27-47.34μM and is more potent when bound to zinc (29.08-31.17μM).  And synthetic derivatives have been made (5,7-Dihydroxy-6-methoxy-4'-phenoxyflavone) with comparable potency than methylphenidate. manufacturers, food companies, and industry funders. Wogonin is also a GABAA agonist with a Ki of 2.03+/-0.24µM at the benzodiazepine binding site.. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Scutellaria baicalensis also known as Huang Qin or Chinese Skullcap is a flowering plant belonging to family Lamiaceae; it is considered as one of 50 fundamental herbs in Chinese medicine. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. Common Name: Skullcap root, Scullcap, Skullcap, Scullcap root, Hoodwort, Quaker bonnet, Helmet flower, European skullcap, Greater skullcap, American skullcap, Blue skullcap, Blue pimpernel, Hooded willow herb, Side-flowering skullcap, Mad dog weed, Mad weed, Virginian Skullcap Botanical Name: Scutellaria Baicalensis Radix Few adverse reactions have been reported. These uses have been supported by clinical trials. Common Name (s): Baical skullcap, Chinese skullcap, Golden root, Huang chin, Huang lien, Huang-qin, Hwang-keum, Hwanggum, Koganebana, Senohgon, Whang-geum, Wogon. Scutellaria lateriflora(Skullcap/Scullcap, Virginia Skullcap, Blue Pimpernel, Helmet Flower, Hoodwort, Mad-dog Weed, Madweed, Madderweed, Mad-Dog Skullcap, Quaker Bonnet/Hat) Habitat: Chinese skullcap is native to eastern Asia. Flavonoids from Baikal skullcap exerted a protective effect on hippocampal neurons by reducing lipid peroxidation build up and glial cell proliferation.59 In a murine model of okadaic acid-induced neuronal damage, S. baicalensis reduced neuronal injuries in the hippocampus and cerebral cortex. It appears to be a good source for flavonoid compounds, and some components are quite potent. , Administration of isolated flavonoids at 5mg/kg noted relatively quick absorption and peaks values, with Tmax values being measured at 5.00m (baicalin), 12.0+/-10.4m (wogonin), and 4.33+/-1.15m (oroxylin A) and reaching respectively Cmax values of 1.10+/-0.49µg/mL (baicalin), 0.57+/-0.14µg/mL (wogonin), and 0.24+/-0.08µg/mL (oroxylin A). Contraindications have not been identified. Scutellaria baicalensis, or Huang Qin, is a valuable herb in eastern medicine. IL-12 is an important cytokine that maintains systemic defense and bioregulation.41 Dry extract of baical skullcap given to 88 lung cancer patients increased hematopoiesis stimulation and improved other anticancer parameters.42 Baicalin and baicalein inhibited cell proliferation in certain cell lines,43 induced quinone reductase,44 and induced apoptosis in prostate cancer cells.45 Other in vitro effects included antigenotoxic actions of baicalein.46, Several studies evaluating the antimicrobial effects of Baikal skullcap have been conducted. Baicalin also demonstrated the most effective inhibition activity when compared with baicalein and wogonin.13 Wogonin, baicalein, and baicalin all have been found to influence some anti-inflammatory pathways via certain proteins, antigens, and enzymes.14, 15, 16, A standardized and purified extract of S. baicalensis containing baicalein, oroxylin A, and wogonin exerted anti-inflammatory effects in both in vitro and in vivo models of colitis. All factual claims are , Components of scutellaria baicalensis have demonstrated lipid and cholesterol lowering effects secondary to AMPK activation in vitro.. , Oroxylin A has been noted to increase CREB and BDNF phosphorylation in cognitively injured mice at 5mg/kg oral intake and mice with beta-amyloid induced memory impairments or to 400% of control mice (no cognitive impairment) at 50μM which is due to activating ERK1/2 (an MAPK), this is downstream of GABAA antagonism, as it was mimicked by bicuculline, and blocked by inhibiting NMDA receptors. Suitable for: light (sandy), medium (loamy) and heavy (clay) soils. Baikal skullcap (scientific name Scutellaria baicalensis) is a plant. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. , The rate of conjugation appears to be lesser when the three main flavonoids are coingested relative to when they are taken in isolation, which is thought to be due to competition by glucuronidation enzymes. Common Name: Baikal Skullcap: Latin Name: Scutellaria baicalensis: Grown: Certified Organically Grown (OG) Form: Fresh root: Origin: Our farm: Availabilty: Call in Summer Inhibition of lipoxygenase may also explain baicalein’s hypotensive effects.12, Baicalein reduced thrombin-mediated fibrin polymerization, prolonged activated partial thromboplastin time and prothrombin time, reduced platelet aggregation, decreased FeCl3-induced thrombus formation, and inhibited activated factor X and thrombin activity. This may be biologically relevant as some evidence suggest a hypothermic effect due to cutaneous vasodilatation in a dose-dependent manner.  The peaks reached in this study were recorded for baicalein (Cmax of 2228+/-463ng/mL at a Tmax of 0.23+/-0.09h), baicalin (13306+/-2626ng/mL at 0.30+/-0.07h), wogonoside (816.4+/-144.9ng/mL at 0.60+/-0.15h), wogonin (2526+/-378ng/mL at 0.33+/-0.20h), oroxylin A (471.6+/-115.4ng/mL at 0.20+/-0.07h), and chrysin (90.22+/-19.55ng/mL at 0.40+/-0.15h). In a phase 1 study of healthy volunteers, baicalein 100 to 2,800 mg was not associated with hepatic or kidney toxicity. , Scutellarin is able to suppress adipocyte differentiation at 100μM (but not 50μM) associated with downregulation of adipogenic transcription factors (PPARγ and C/EBPα, no influence on C/EBPβ) and upregulation of PPARα and no influence on PPARδ. Uses and Markets: Medicinal (e.g. The dried root is used in traditional Chinese medicine. Common Name: Baikal Skullcap - Huang-Qin: Family: Lamiaceae or Labiatae: USDA hardiness: 4-8: Known Hazards: Liver toxicity (hepatotoxicity). It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. , Oroxylin A appears to be able to inhibit the P-glycoprotein (P-gp) transporter in the range of 5-40μM and has shown efficacy at an oral intake of 50mg/kg to rats altering paclitaxel pharmacokinetics.. , Sleep induced in light phases (equivalent of daytime) seems to actually be hindered by baicalin, thought to be from interfering with an IL-1β induced slow wave sleep enhancement. We comply with the HONcode standard for trustworthy health information -, http://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. Baicalein induced apoptosis of these colorectal cancer cells. Plant Family: Lamiaceae. , Baicalin appears to involve intestinal microflora for its metabolism into baicalein (via removal of the glucuronide group), as decreasing intestinal microflora alters the kinetics of the flavonoid. , Scutellaria baicalensis is a component of various combination therapies (from TCM) including Ger-Gen-Chyn-Lian-Tang (rhizome of Coptidis chinensis paired with the roots of Pueraria Lobata, licorice, and scutellaria baicalensis), Soshiho-tang (Bupleurum falcatum, licorice, panax ginseng, ginger, ziziphus jujuba, and Pinellia ternata with scutellaria baicanelsis), and shuanghuanglian (forsythiae fruits and honeysuckle with scutellaria baicanelsis). 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