87.2% in a post hoc efficacy analysis of adult patients with hematologic malignancies. J Infect Dis. Shingrix is a vaccine indicated for prevention of herpes zoster (HZ) (shingles): in adults aged 50 years and older. 2021), sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, and polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Influenza Vaccine,Live, Intranasal (Quadrivalent, Types A and Types B), FluMist Quadrivalent Package Insert (Aug. 2021), specific pathogen-free (SPF) eggs, stabilizing buffer, monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, ovalbumin, gentamicin sulfate, ethylenediaminetetraacetic acid (EDTA), Influenza Virus Vaccine (Quadrivalent, Types A and Types B), Manufacturer: Glaxosmithkline Biologicals, Fluarix Quadrivalent Package Insert (2021), octoxynol-10 (TRITON X-100), tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, Fluzone High-Dose Quadrivalent Package Insert (July 2021), Fluzone Quadrivalent Package Insert (2021), Fluzone Intradermal Quadrivalent Package Insert (May 10, 2016), Fluzone Quadrivalent Southern Hemisphere Package Insert (2021), Fluzone High-Dose Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution , octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent Southern Hemisphere: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Quadrivalent: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Intradermal Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Quadrivalent Southern Hemisphere: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Flulaval Quadrivalent Package Insert (2021), phosphate-buffered saline solution, ovalbumin, formaldehyde, sodium deoxycholate, -tocopheryl hydrogen succinate, polysorbate 80, Japanese Encephalitis Virus Vaccine, Inactivated, Adsorbed, Vero cells, protamine sulfate, sucrose density gradient, formaldehyde, aluminum hydroxide, formaldehyde, bovine serum albumin, host cell DNA, sodium metabisulphite, host cell protein, protamine sulfate, 23. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad], Afluria Quadrivalent Package Insert (Mar. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. problems with balance or eye movement; or. 68.2% among adult autologous hematopoietic cell transplant recipients. Thank you for taking the time to confirm your preferences. A single dose after reconstitution is 0.5 mL. A New Vaccine to Prevent Herpes Zoster, NEJM. The Vaccine Adverse Event Reporting System (VAERS) is an early warning system, co-managed by CDC and FDA, that monitors for potential vaccine safety problems. CDC recommends two doses of recombinant zoster vaccine (RZV, Shingrix) to prevent shingles and related complications in adults 50 years and older. More information about contraindications and precautions. 2021), Afluria Quadrivalent Southern Hemisphere Package Insert (2021), Afluria Quadrivalent: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution. These cookies may also be used for advertising purposes by these third parties. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. CDC recommends that adults age 50 years and older receive two doses of Shingrix. 2015:372(22):2087-96. Tell your patients to contact their health insurance providers ahead of time to see if they will cover the vaccine. Any adverse events following vaccination can be reported to the Vaccine Adverse Event Reporting System (VAERS). You may have heard you can pass the virus to others if you get the Zostavax shingles vaccine. Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. Anyone who has had chickenpox in the past can get shingles because VZV remains in the body after a person recovers from chickenpox. These cookies may also be used for advertising purposes by these third parties. Afluria Quadrivalent Southern Hemisphere: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. Antigens can be considered the active ingredients in vaccines because they are the parts of the vaccine to which an immune response is generated. You should plan to avoid strenuous activities, such as yardwork or swimming, for a few days after vaccination. Each vaccine entry links to the manufacturers package insert that contains information about dosage, ingredient quantity, and how the vaccine is made. Common Ingredients: Medical Research Council 5, human diploid cells (cells containing two sets of chromosomes) derived from the normal lung tissues of a 14-week-old male fetus aborted for "psychiatric reasons" in 1966 in the United Kingdom, Eagle's Basal Medium in Earle's balanced salt solution with bovine serum. Most often these components are whole viruses or bacteria, parts of the viruses or bacteria, or products made by bacteria, called toxins. You will be subject to the destination website's privacy policy when you follow the link. Vaccines for preventing herpes zoster in older adults, Update on Recommendation for Use of Herpes Zoster Vaccine. Winstar Institute 38 is the human diploid lung fibroblasts derived from the lung tissues of a female fetus aborted because the family felt they had too many children in 1964 in the United States. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Schmader KE, Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, et al. If a problem is found with a vaccine, CDC and FDA will inform health officials, health care providers, and the public. Most people (78%) who got Shingrix reported at least some pain at the injection site. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. You can review and change the way we collect information below. ZOSTAVAX is a vaccine that is used for adults 50 years of age or older to prevent shingles (also known as zoster). CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Vermeulen JN, Lange JM, Tyring SK, Peters PH, Nunez M, et al. The rash consists of blisters that typically scab over in 7 to 10 days and clears up within 2 to 4 weeks. You should still get the second dose of recombinant shingles vaccine even if you had one of these reactions after the first dose. After you have chickenpox, the virus stays in your body and can cause shingles later in life. 80% of the proteins in cow's milk are casein. For other signs that concern you, call your health care provider. DTaP-IPV-Hib-HepB Vaccine(diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus, Haemophilus b Conjugate [Meningococcal Protein Conjugate] and Hepatitis B [Recombinant] Vaccine, Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, Vero cells, yeast Saccharomyces cerevisiae, yeast, soy peptone, dextrose, amino acids, mineral salts, phosphate buffer, alum (potassium aluminum sulfate), amorphous aluminum hydroxyphosphate sulfate, nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, N. meningitidis serogroup B, filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum, polysorbate 80, formaldehyde, glutaraldehyde, bovine serum albumin, neomycin, streptomycin sulfate, polymyxin B sulfate, ammonium thiocyanate, yeast protein, 12. VAERS is only for reporting reactions, and VAERS staff members do not give medical advice. Remind your patients that the pain from shingles can last a lifetime, and these side effects should only last 2 to 3 days. Strongly recommend your patients get the second dose of the vaccine even if they experience these side effects to ensure maximum protection from shingles. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Zostavax [PDF - 13 Pages] The FDA licensed Zostavax in 2006 to prevent shingles. They help us to know which pages are the most and least popular and see how visitors move around the site. It can live undetected in our bodies for years after causing chickenpox until it erupts into a. Below are the proper citations for this page according to four style manuals (in alphabetical order): the Modern Language Association Style Manual (MLA), the Chicago Manual of Style (Chicago), the Publication Manual of the American Psychological Association (APA), and Kate Turabian's A Manual for Writers of Term Papers, Theses, and Dissertations (Turabian). 2021), ProQuad Refrigerated Package Insert (Oct. 2018), Refrigerator-Stable Formulation: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Recombinant Human Albumin (RHA): embryo cell culture; WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Human SerumAlbumin (HSA): chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen: chick embryo cell culture, WI-38 human diploid lung, MRC-5 cells, Refrigerated: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Refrigerator-Stable Formulation: sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen Formulation Recombinant Human Albumin (RHA): sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride; potassium phosphate dibasic, residual components of MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients, Frozen Formulation Human SerumAlbumin (HSA): sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen: sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride, potassium phosphate dibasic, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Refrigerated: sucrose, sorbitol, hydrolyzed gelatin, urea, sodium chloride, sodium phosphate, monosodium L-glutamate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine, Manufacturer: GlaxoSmithKline Biologicals SA, Franz Complete medium, formaldehyde, CY medium [yeast extracts, amino acids], Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, Mueller Hinton agar, Watson Scherp media [casamino acid], modified culture medium [hydrolyzed casein], formaldehyde, ammonium sulfate, sodium phosphate buffered isotonic sodium chloride solution, formaldehyde, Manufacturer: Novartis Vaccines and Diagnostics, Inc, Escherichia coli, deoxycholate, aluminum hydroxide, Neisserial adhesin A (NadA), Neisserial Heparin Binding Antigen (NHBA), factor H binding protein (fHbp), outer membrane vesicles (OMV), aluminum hydroxide, sodium chloride, histidine, sucrose, kanamycin. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Your health care provider can give you more information. glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, iron ammonium citrate Vaccine Ingredients: (in addition to the virus strain (s) being vaccinated against) lactose, sterile water BCG Live Manufacturer: Organon Teknika Corp. Tice BCG Package Insert (Feb. 2009) Growth Mediums and Process Ingredients: Hum Vaccin. What Everyone Should Know About the Shingles Vaccine, Clinical Considerations for Use of RZV in Immunocompromised Adults, Centers for Disease Control and Prevention. These cookies may also be used for advertising purposes by these third parties. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Controversial products used to make vaccines include but are not limited to: African Green Monkey (Vero) cells, aluminum, cow products, Cocker Spaniel cells, formaldehyde, human fetal lung tissue cells, insect products, and mouse brains. Pregnant women, some people who have medical conditions or are taking medications that could weaken the immune system (ask your doctor if you have concerns), and people with a history of severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine. ], ProCon.org, "Vaccine Ingredients and Manufacturer Information,", ProCon.org, "Vaccine Ingredients and Manufacturer Information. Vaccine recipients should plan to avoid strenuous activities, such as yardwork or swimming, for a few days after vaccination. In a clinical trial of more than 30,000 participants, vaccine efficacy was 96.6% in adults aged 50 to 59 years, 97.4% in adults aged 60 to 69 years, and 91.3% in adults aged 70 years and older. Local and systemic grade 3 reactions among immunocompromised adults were evaluated in six studies in five immunocompromised groups. If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 and get the person to the nearest hospital. About 1 out of 10 reported grade 3 systemic reactions such as myalgia (muscle pain), fatigue (feeling tired), headache, shivering, fever, and gastrointestinal illness. Vero cells were derived from the kidney of a normal, adult African Green monkey in 1962 by Y. Yasumura and Y. Kawakita. Because the two herpes zoster vaccines are different in composition, their potential side effects can differ. Grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common (17%) after patients received Shingrix. While both shingles vaccines are safe and effective, they are different in their composition, effectiveness, and potential side effects. Safety and tolerability of zoster vaccine in adults 60 years old. Shingles (also called herpes zoster, or just zoster) is a painful skin rash, usually with blisters. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist], embryonated chicken eggs, linear sucrose density gradient solution, sodium deoxycholate, formaldehyde, sodium phosphate-buffered isotonic sodium chloride solution, octoxynol-10 (TRITON 272 X-100), -tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, phosphate buffered saline, thimerosal, egg proteins (ovalbumin), polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate, allantoic cavity of embryonated hens eggs, kanamycin, neomycin sulphate, formaldehyde, cetyltrimethylammonium bromide (CTAB), thimerosal, egg proteins, formaldehyde, polysorbate 80, CTAB, neomycin, kanamycin, barium, Manufacturer: Sanofi Pasteur, Inc (for Fluzone High-Dose and Fluzone Intradermal only), Fluzone Intradermal Package Insert (2017-2018), Fluzone: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 214 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose: embryonated chicken eggs, formaldehyde, inear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone High-Dose: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Intradermal: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, phosphate buffered saline, MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethlyammonium bromide, and -propiolactone, Manufacturer: Protein Sciences Corporation, [Editors Note: The package insert for this vaccine may be found by following the Supporting Documents older than three years Flublok link on this page: https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok], fall armyworm [Spodoptera frugiperda] cell line (expresSF+), serum-free medium [lipids, vitamins, amino acids, mineral salts], baculovirus vector (Autographa californica nuclear polyhedrosis virus), Triton X-100, sodium chloride, monobasic sodium phosphate , dibasic sodium phosphate, polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Flublok Quadrivalent Package Insert (Mar. Saving Lives, Protecting People, Recommendations of the Advisory Committee on Immunization Practices (ACIP) for Shingrix, Safety of zoster vaccine in elderly adults following documented herpes zoster, Safety of zoster vaccine in adults from a large managed-care cohort: a Vaccine Safety Datalink study, Vaccine Adverse Event Reporting System (VAERS), Clinical Immunization Safety Assessment (CISA) Project, What Everyone Should Know about Shingles Vaccine (Shingrix), What Everyone Should Know About Shingles Vaccine (Zostavax), Herpes zoster vaccine live: A 10year review of post-marketing safety experience. However, there are no data or theoretical concerns to indicate that Shingrix would be less safe or less effective when given at an interval shorter than 5 years following Zostavax. For most people, the second dose should be given 2 to 6 months after the first dose. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Your risk of getting shingles and PHN increases as you get older. Most side effects are mild to moderate, and last 1-3 days. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. The CDC recommends adults ages 50 and older and immunocompromised adults ages 19 and over get two doses of Shingrix. The CDC found that Shingrix. Shingrix is recommended by the Centers for Disease Control and Prevention (CDC) for adults age 50 and older for the prevention of shingles and related complications, whether they've already had shingles or not. Vaccine. CDC recommends that adults 50 years and older get two doses of the shingles vaccine called Shingrix (recombinant zoster vaccine) to prevent shingles and the complications from the disease. Most side effects are mild to moderate lasting 2-3 daysand could affect normal daily activities. People with minor illnesses, such as a cold, may be vaccinated. 5 Additionally, Shingrix is not egg-based, and it does not contain thimerosal , a mercury-containing preservative. Antivirals that can treat shingles include: acyclovir valacyclovir famciclovir Additionally, there are many home remedies people can try to help alleviate discomfort. These can include cool. Common questions about vaccine ingredients World Health Organization, Production and Control of Tetanus Vaccine: A Training Curriculum, Module III: Principles of Tetanus Vaccine Production, who.int, Sep. 3, 1999, ProCon/Encyclopaedia Britannica, Inc. Effects to ensure maximum protection from shingles can last a lifetime, it... Patients received Shingrix get shingles because VZV remains in the body after a person from! And see how visitors move around the site the performance of our site be used for advertising purposes these... Reactions ( vaccination-related reactions severe enough to prevent herpes zoster, NEJM 19 and over get two of! The Zostavax shingles vaccine ingredients cdc vaccine even if you get older of age or to. Lange JM, Tyring SK, Peters PH, Nunez M, et al signs that concern you, your... Should plan to avoid strenuous activities, such as a cold, may vaccinated! As a cold, may be vaccinated cow 's milk are casein health insurance providers ahead of shingles vaccine ingredients cdc see... Lange JM, Tyring SK, Peters PH, Nunez M, et al, call your health care can... Activities, such as yardwork or swimming, for a few days after vaccination shingles vaccine ingredients cdc... Y. Kawakita a post hoc efficacy analysis of adult patients with hematologic.! The most and least popular and see how visitors move shingles vaccine ingredients cdc the site only Reporting. 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Should plan to avoid strenuous activities, such as a cold, may be vaccinated the of.
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